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Reconstitution of huPBL-NSG Mice with Donor-Matched Dendritic Cells Enables Antigen-Specific T-cell Activation

✍ Scribed by Harui, Airi; Kiertscher, Sylvia M.; Roth, Michael D.


Book ID
107380755
Publisher
Springer US
Year
2010
Tongue
English
Weight
347 KB
Volume
6
Category
Article
ISSN
1557-1890

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## Abstract ## Background Genetic modification of human monocyte‐derived dendritic cells (DC) with cDNA sequences encoding tumor‐associated antigens (TAA) is a promising strategy for cancer immunotherapy. The present study aimed to develop a nonviral gene transfer method based on the use of the ca