D-penicillamine has been used to treat systemic sclerosis (scleroderma) for nearly two decades. Improvement in cutaneous fibrosis in patients treated with this drug has been documented in a number of uncontrolled studies (1). The effect of D-penicillamine on established visceral involvement due to s
✦ LIBER ✦
Recommendations for the care of oral involvement in patients with systemic sclerosis
✍ Scribed by Alp Alantar; Jean Cabane; Eric Hachulla; Guy Princ; Danielle Ginisty; Michel Hassin; Marc Sorel; Louis Maman; Aurélie Pilat; Luc Mouthon
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2011
- Tongue
- English
- Weight
- 126 KB
- Volume
- 63
- Category
- Article
- ISSN
- 2151-464X
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## Abstract ## Objective Increased endothelin activity may play a role in the pathogenesis of vascular injury, a primary feature of systemic sclerosis (SSc; scleroderma). Our goal was to test the hypothesis that treatment with the oral endothelin receptor antagonist bosentan might improve vascular
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