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Recombination and joining: different means to the same ends

โœ Scribed by Roland Kanaar; Jan Hoeijmakers

Book ID
104464078
Publisher
Blackwell Publishing
Year
1997
Tongue
English
Weight
303 KB
Volume
1
Category
Article
ISSN
1360-7413

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โœฆ Synopsis

DNA doubleโ€strand breaks are very genotoxic lesions that can result in chromosome aberrations. The current view is that DNA doubleโ€strand breaks are repaired most efficiently through homologous recombination in yeast and simple endโ€joining in mammalian cells. However, recent experiments reveal that both repair pathways are conserved from yeast to mammals, including humans. The challenge ahead is to put the different pieces of the jigsaw together into coherent mechanisms for both pathways and to determine their relative contributions to ionizingโ€radiation resistance and to the prevention of genetic instability and carcinogenesis.

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The end-joining pathway of DNA double-strand break (DSB) repair is necessary for proper V(D)J recombination and repair of DSB caused by ionizing radiation. This DNA repair pathway can either use short stretches of (micro)homology near the DNA ends or use no homology at all (direct end-joining). We d