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Recombinant γ-interferon inhibits prostaglandin-mediated and parathyroid hormone-induced bone resorption in cultured neonatal mouse calvaria

✍ Scribed by Meinrad Peterlik; Oskar Hoffmann; Peter Swetly; Klaus Klaushofer; Kristian Koller

Book ID: 115917205
Publisher: Elsevier Science
Year: 1985
Tongue: English
Weight: 414 KB
Volume: 185
Category: Article
ISSN: 0014-5793
DOI: 10.1016/0014-5793(85)80924-8

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The cytokine interleukin-6 (IL-6) was produced by neonatal mouse parietal bones during a 6- or 48-hour culture period in response to prostaglandin E2 (PGE2) and bovine parathyroid hormone (PTH) 1-34 fragment but not 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. At the same time there was an increase in ta