Thirty-three patients with measurable metastatic renal cell carcinoma were entered into 2 consecutive phase II protocols using interferon alfa-2a. In protocol I, 20 patients were treated with interferon alfa-2a at a dose of 36 x I06 IU i.m. t.i.w. Vinblastine was also given t o 18 of these patients
Recombinant interferon alfa-2a with or without vinblastine in metastatic renal cell carcinoma
✍ Scribed by Sophie D. Fossåu; Stephen T. De Garis; Mona S. Heier; Asbjøsrn Flokkmann; Hans H. Lien; Aud Salveson; Brit Moe
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 552 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0008-543X
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Background. Prolonged therapy with interferon (IFN) may lead to the formation of IFN antibodies. Methods. Patients with renal cell carcinoma (n = 270) with advanced localized disease were randomized after complete tumor resection to receive treatment with adjuvant recombinant IFN-alpha-2a (rIFN-a2a
Five partial responses were seen in 23 patients with metastatic renal-cell carcinoma (MRCC) receiving interferon-a 2a (IFN) + prednisone (P). Four of 24 subsequent patients responded to IFN + P (combined response rate 19%). The median response duration was 8 months (3 to 30 months). The one-year sur