An evaluation of recombinant leukocyte a interferon with aspirin in patients with metastatic renal cell cancer
β Scribed by Edward T. Creagan; Jan C. Buckner; Richard G. Hahn; Ronald R. Richardson; Daniel J. Schaid; John S. Kovach
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 510 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0008-543X
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π SIMILAR VOLUMES
Background. Prolonged therapy with interferon (IFN) may lead to the formation of IFN antibodies. Methods. Patients with renal cell carcinoma (n = 270) with advanced localized disease were randomized after complete tumor resection to receive treatment with adjuvant recombinant IFN-alpha-2a (rIFN-a2a
Thirty-three patients with measurable metastatic renal cell carcinoma were entered into 2 consecutive phase II protocols using interferon alfa-2a. In protocol I, 20 patients were treated with interferon alfa-2a at a dose of 36 x I06 IU i.m. t.i.w. Vinblastine was also given t o 18 of these patients