Until quite recently, recombinant DNA technology was not able to deal with DNA molecules larger than 20-40 kb. This is a serious limitation for the study of mammalian, and in particular human genomes whose total length is approx. 3 x 106 kb, since the best resolution of genetic and chromosomal analy
Recombinant DNA techniques in diagnostic and preventive medicine
β Scribed by Stephen Hodgkinson; Peter Scambler
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 446 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
The introduction of recombinant DNA technology into the field of genetics has led to a rapid advancement of our knowledge of genes and genome structure. Such technology, applied to the human genome, has provided valuable information concerning the nature and possible treatment of inherited disorders. The possibility that this knowledge will pave the way for the correction of at least some of these disorders has captured the imagination of the informed public. In this review we look at the accomplishments of molecular pathologists to date and how new techniques are being applied to the study of inherited disease.
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