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Recognition of nonpalindromic DNA sequence by a peptide heterodimer with artificial dimerization module

✍ Scribed by Ueno, Masaru; Sawada, Mamoru; Makino, Keisuke; Morii, Takashi

Book ID: 126429601
Publisher: American Chemical Society
Year: 1994
Tongue: English
Weight: 855 KB
Volume: 116
Category: Article
ISSN: 0002-7863
DOI: 10.1021/ja00103a031

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**The cover picture shows** a representation of a new DNA‐recognition strategy based on clamping dsDNA by the simultaneous interaction of a tripyrrole and the basic region of transcription factor GCN4 with two contiguous DNA sites. The peptide unit by itself is incapable of tight specific DNA bindin