Sequence-Specific DNA Recognition by Monomeric bZIP Basic Regions Equipped with a Tripyrrole Unit on the N-Terminal Side. Towards the Development of Synthetic Mimics of Skn-1

Cover Picture: Sequence-Specific DNA Rec

Cover Picture: Sequence-Specific DNA Recognition by Monomeric bZIP Basic Regions Equipped with a Tripyrrole Unit on the N-Terminal Side. Towards the Development of Synthetic Mimics of Skn-1 (ChemBioChem 12/2005)

✍ Juan B. Blanco; M. Eugenio Vázquez; Luis Castedo; José L. Mascareñas 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 48 KB 👁 1 views

**The cover picture shows** a representation of a new DNA‐recognition strategy based on clamping dsDNA by the simultaneous interaction of a tripyrrole and the basic region of transcription factor GCN4 with two contiguous DNA sites. The peptide unit by itself is incapable of tight specific DNA bindin