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Reciprocal regulation of glycogen phosphorylase and glycogen synthase by insulin involving phosphatidylinositol-3 kinase and protein phosphatase-1 in HepG2 cells

✍ Scribed by Noor A. Syed; Ramji L. Khandelwal


Book ID
110248935
Publisher
Springer
Year
2000
Tongue
English
Weight
358 KB
Volume
211
Category
Article
ISSN
0300-8177

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In order to study the role of phosphatidylinositol-3-kinase (PI3K), PKB, FRAP, S6 kinase, and MAP kinase in insulin-stimulated glycogen synthesis, we used a specific inhibitor of PI3K, LY294002, the immunosuppressant inhibitor of FRAP, rapamycin, and the inhibitor of MAPK kinase (MEK)/MAPK, PD98059,