Reciprocal balanced translocation of the long arm of chromosome 8 to the short arm of chromosome 7 in a woman with two spontaneous abortions
โ Scribed by H. Hatzissevastou-Loukidou; A. Bouli-Kalachani; A. Malaka-Zafiriou; S. Mantalenakis
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 32 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0340-6717
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Loss of heterozygosity (LOH) from the short arm of chromosome 8 (8p) is frequent in many human cancers, including breast, colon, prostate. and bladder cancers. LOH occurs in two regions of 8p, 8p2I and 8p22, and suggests the presence of two separate tumor suppressor genes. In breaa cancers, 8p LOH O