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Reciprocal Activation of CD4+ T Cells and Synovial Fibroblasts by Stromal Cell-Derived Factor 1 Promotes RANKL Expression and Osteoclastogenesis in Rheumatoid Arthritis

✍ Scribed by Kim, Hae-Rim; Kim, Kyoung-Woon; Kim, Bo-Mi; Jung, Hong-Geun; Cho, Mi-La; Lee, Sang-Heon


Book ID
121807686
Publisher
Wiley (John Wiley & Sons)
Year
2014
Tongue
English
Weight
794 KB
Volume
66
Category
Article
ISSN
2326-5191

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Up-regulation of stromal cell–derived fa
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## Abstract ## Objective Stromal cell–derived factor 1 (SDF‐1) is a potent chemoattractant for memory T cells in inflamed rheumatoid arthritis (RA) synovium. This study was undertaken to investigate the effect of interleukin‐17 (IL‐17) and CD40–CD40L interaction on SDF‐1 production in RA fibroblas