Rechallenge in clozapine-induced agranulocytosis
โ Scribed by Safferman, AllanZ; Lieberman, JeffreyA; Alvir, JoseMa.J; Howard, Alfreda
- Book ID
- 122427160
- Publisher
- The Lancet
- Year
- 1992
- Tongue
- English
- Weight
- 334 KB
- Volume
- 339
- Category
- Article
- ISSN
- 0140-6736
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An epidemic of agranulocytosis and granulocytopenla occurred in 1975 in conjunction with clozapine treatment of mental patients in Finland. An attempt was made to assess the epidemiologic and genetic factors contributing to the adverse drug effect. The estimated incidence rate in Finland was 2.1,/10
Clozapine is an atypical antipsychotic with a signiยฎcant incidence of agranulocytosis. Olanzapine resembles clozapine structurally; however, it lacks a halogen, which has been implicated in agranulocytosis. Both agents have a similar pharmacological proยฎle. We therefore studied olanzapine in patient