An epidemic of agranulocytosis and granulocytopenla occurred in 1975 in conjunction with clozapine treatment of mental patients in Finland. An attempt was made to assess the epidemiologic and genetic factors contributing to the adverse drug effect. The estimated incidence rate in Finland was 2.1,/10
Clozapine-induced agranulocytosis
โ Scribed by Anger, B. ;Reichert, S. ;Heimpel, H.
- Publisher
- Springer-Verlag
- Year
- 1987
- Weight
- 106 KB
- Volume
- 54
- Category
- Article
- ISSN
- 1432-0584
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Clozapine is an atypical antipsychotic with a signiยฎcant incidence of agranulocytosis. Olanzapine resembles clozapine structurally; however, it lacks a halogen, which has been implicated in agranulocytosis. Both agents have a similar pharmacological proยฎle. We therefore studied olanzapine in patient
Although toxicity and inborn errors of metabolism may also be involved, immunological reactions play an important role in the induction of drug-induced agranulocytosis. Drug-induced antibodies may lead to agranulocytosis by at least three different immunological mechanisms. Immune complexes may sele