Receptor tyrosine kinases: Getting on TRK
β Scribed by Novak, Kristine
- Book ID
- 109947308
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 107 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1474-1776
- DOI
- 10.1038/nrc1519
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Nerve growth factor (NGF) initiates the majority of its biological effects by promoting the dimerization and activation of the tyrosine kinase receptor TrkA. In addition to rapid increases in the phosphorylation of phosphatidylinositol 3Πkinase (PI 3-kinase) and phospholipase C-β₯ and increased ras a
The present report describes the in vitro and in vivo profile of CEP-751, a novel receptor tyrosine kinase inhibitor. CEP-751 at 100 nM inhibits the receptor tyrosine kinase activity of the neurotrophin receptors trkA, trkB and trkC. CEP-751 has no effect on activity of receptors for EGF, IGF-I, ins