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Receptor editing in lymphocyte development and central tolerance

โœ Scribed by Nemazee, David


Book ID
109955544
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
582 KB
Volume
6
Category
Article
ISSN
1474-1741

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Receptor editing and commitment in B lym
โœ Marc Hertz; David Nemazee ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 558 KB

B cells that fail to pass a developmental checkpoint, either as immature or mature B cells, can be rescued by creating a new B cell antigen receptor through nested secondary immunoglobulin gene rearrangements, a process termed receptor editing. Tolerance-mediated receptor editing occurs in self-reac