Receptor editing and commitment in B lymphocytes

✍ Scribed by Marc Hertz; David Nemazee

• Book ID: 104358969
• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 558 KB
• Volume: 10
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/s0952-7915(98)80250-1

✦ Synopsis

B cells that fail to pass a developmental checkpoint, either as immature or mature B cells, can be rescued by creating a new B cell antigen receptor through nested secondary immunoglobulin gene rearrangements, a process termed receptor editing. Tolerance-mediated receptor editing occurs in self-reactive immature bone marrow B cells, while peripheral receptor editing probably occurs in low-affinity B cells competing for antigen and for survival signals within the germinal center response.