Receptor binding and biological effects of three 125I-iodinated estrogen derivatives in human breast cancer cells (MCF-7)
✍ Scribed by Souttou, Boussad; Moretti, Jean-Luc; Gros, Jacques; Guilloteau, Denis; Crepin, Michel
- Book ID
- 123452933
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 946 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0960-0760
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## Abstract We show that flavonoids positively regulate type‐II estrogen‐binding site (type‐ll EBS) levels both in MCF‐7 (ER‐positive) and in MDA‐MB231 (ER‐negative) breast‐cancer cells. Type‐ll EBS were measured by a whole‐cell assay at 4°C for 2.5 hr using [^3^H]‐estradiol as tracer. In both cell