Recent Trends in the Nucleophilic [18F]-radiolabeling Method with No-carrier-added [18F]fluoride
✍ Scribed by Dong Wook Kim; Hwan-Jeong Jeong; Seok Tae Lim; Myung-Hee Sohn
- Book ID
- 107686962
- Publisher
- Springer-Verlag
- Year
- 2010
- Tongue
- English
- Weight
- 410 KB
- Volume
- 44
- Category
- Article
- ISSN
- 1869-3474
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## Abstract The scope of the nucleophilic aromatic __ortho__‐fluorinations from the corresponding __ortho__‐halonitrobenzene precursors (halo‐to‐fluoro substitutions) with no‐carrier‐added [^18^F]fluoride ion as its activated K[^18^F]F–K~222~ complex has been evaluated via the radiosynthesis of __o
No-carrier-added trimethylsilyl[18F]fluoride (TMS[18F]F) was rapidly liberated from a variety of dry supports containing unreactive [18F]fluoride by simply heating with neat bistrimethylsilylsulfate. The supports included calcium phosphate, anion exchange resins, alumina, borosilicate and porous car
The scope of the nucleophilic aromatic substitution reaction of 2-substituted pyridines with nocarrier-added [ \(\left.{ }^{13} \mathrm{~F}\right]\) fluoride ion (half life : 110 minutes) as its \(\left[{ }^{18} \mathrm{~F}\right] \mathrm{FK}-\mathrm{K}_{222}\) activated complex, has been evaluated