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Recent Progress in Understanding the Mechanism of P-Glycoprotein-mediated Drug Efflux

โœ Scribed by T.W. Loo; D.M. Clarke


Publisher
Springer
Year
2005
Tongue
English
Weight
275 KB
Volume
206
Category
Article
ISSN
0022-2631

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In Vitro absorption and secretory quotie
โœ Victoria E. Thiel-Demby; Timothy K. Tippin; Joan E. Humphreys; Cosette J. Serabj ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 92 KB ๐Ÿ‘ 1 views

The absorptive (AQ) and secretory (SQ) quotients have been proposed as a novel experimental approach to quantify the modulation of intestinal absorption and secretion by P-glycoprotein (Pgp). Because these unidirectional assays inherently assess for the impact of Pgp, conclusions as to whether a com