A Continuous Fluorescence Assay for the Study of P-Glycoprotein-Mediated Drug Efflux Using Inside-Out Membrane Vesicles

In Vitro absorption and secretory quotie

In Vitro absorption and secretory quotients: Practical criteria derived from a study of 331 compounds to assess for the impact of P-glycoprotein-mediated efflux on drug candidates

✍ Victoria E. Thiel-Demby; Timothy K. Tippin; Joan E. Humphreys; Cosette J. Serabj 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 92 KB 👁 1 views

The absorptive (AQ) and secretory (SQ) quotients have been proposed as a novel experimental approach to quantify the modulation of intestinal absorption and secretion by P-glycoprotein (Pgp). Because these unidirectional assays inherently assess for the impact of Pgp, conclusions as to whether a com