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Recent progress in the development of coumarin derivatives as potent anti-HIV agents

✍ Scribed by Donglei Yu; Madoka Suzuki; Lan Xie; Susan L. Morris-Natschke; Kuo-Hsiung Lee

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
318 KB
Volume
23
Category
Article
ISSN
0198-6325

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✦ Synopsis

Abstract

Numerous plant‐derived compounds have been evaluated for inhibitory effects against HIV replication, and some coumarins have been found to inhibit different stages in the HIV replication cycle. This review article describes recent progress in the discovery, structure modification, and structure–activity relationship studies of potent anti‐HIV coumarin derivatives. A dicamphanoyl‐khellactone (DCK) analog, which was discovered and developed in our laboratory, and calanolide A are currently in preclinical studies and clinical trials, respectively. © 2003 Wiley Periodicals, Inc. Med Res Rev, 23, No. 3, 322‐345, 2003

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