Synthesis and Studies of New 2-(Coumarin-4-yloxy)-4,6-(substituted)-s-Triazine Derivatives as Potential Anti-HIV Agents

✍ Scribed by Dharmesh H. Mahajan; Christophe Pannecouque; Erik De Clercq; Kishor H. Chikhalia

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 483 KB
• Volume: 342
• Category: Article
• ISSN: 0365-6233
• DOI: 10.1002/ardp.200800149

✦ Synopsis

Abstract

Novel 2‐(coumarin‐4‐yloxy)‐4,6‐(substituted)‐s‐triazine derivatives i. e., diaryltriazine (DATA) are reported as novel non‐nucleoside reverse transcriptase inhibitors (NNRTIs), were synthesized and their activities against human immunodeficiency virus HIV‐1 (III‐B), HIV‐2 (ROD), and the double RT mutant HIV‐1 (K103N and Y181C) were assessed. Modifications at positions 4 and 6 of the coumarinyl‐triazine scaffold generated interesting derivatives displaying good to moderate anti‐HIV activity against selected HIV strains as compared to nevirapine and efavirenz. The synthesized compounds were characterized by FTIR, ^1^H‐NMR, and mass spectral data together with elemental analysis.