Recent pharmaceutical applications of raman and terahertz spectroscopies
β Scribed by Cushla M. McGoverin; Thomas Rades; Keith C. Gordon
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 548 KB
- Volume
- 97
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
β¦ Synopsis
This review outlines recent applications of Raman and terahertz spectroscopies within the field of pharmaceutical research. Of the two approaches, Raman is better established and more accessible, and is responsible for the majority of reviewed studies. Both techniques feature limitations, however, which are discussed in the context of methods used to circumvent apparent restrictions. Regardless, the diverse range of applications illustrates the flexibility of Raman and terahertz spectroscopies when characterizing pharmaceutical systems.
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Terahertz (THz) spectroscopy and chemometric analysis of resultant absorption spectra in the 30-500 cm(-1) range has been applied to perform quantitative determination of both active ingredient and excipient concentrations of tablets. Tests were performed on a series of tablets composed of various c
## Abstract Terahertz (THz) spectroscopic investigations of condensedβphase biological samples are reviewed ranging from the simple crystalline forms of amino acids, carbohydrates and polypeptides to the more complex aqueous forms of small proteins, DNA and RNA. Vibrationally resolved studies of cr
Recent advances in optical and spectroscopic technologies have enabled a plethora of Raman spectrometers that are suitable for studies of protein pharmaceuticals. Highly sensitive Raman spectrometers have overcome the handicap of the fundamentally weak Raman effect that hampered their applications t