Recent applications of benchmark dose method for estimation of reference cadmium exposure for renal effects in man
✍ Scribed by Yasushi Suwazono; Mirei Uetani; Agneta Åkesson; Marie Vahter
- Book ID
- 116923592
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 144 KB
- Volume
- 198
- Category
- Article
- ISSN
- 0378-4274
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Previously, the association between urinary cadmium (Cd) concentration and indicators of renal dysfunction, including beta(2)-microglobulin (beta(2)-MG), total protein and N-acetyl-beta-D-glucosaminidase (NAG) were investigated in 1270 inhabitants > or = 50 years of age (547 men, 723 women) in a Cd
We used an updated hybrid approach to estimate the benchmark doses and their 95% lower confidence limits (BMDL) for cadmium-induced renal effects in humans. Participants were 828 inhabitants (410 men, 418 women), aged 40-59 years who lived in three areas without any known environmental cadmium pollu