✦ LIBER ✦

Recent Advances in Retromer Biology

✍ Scribed by Ian J. McGough; Peter J. Cullen

Book ID: 111268541
Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 889 KB
Volume: 12
Category: Article
ISSN: 1398-9219
DOI: 10.1111/j.1600-0854.2011.01201.x

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The cellular origin of H-RS cells has been questioned for a long time. Recently, using single cell amplification of Ig genes evidence was obtained that H-RS cells clonally arise from B-cells. Sequence analysis of rearranged Ig genes demonstrated that H-RS cells develop within the germinal centre. H-