✦ LIBER ✦

Recent advances in minisatellite biology

✍ Scribed by John A.L. Armour; Alec J. Jeffreys

Book ID: 115926589
Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 305 KB
Volume: 307
Category: Article
ISSN: 0014-5793
DOI: 10.1016/0014-5793(92)80912-z

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The cellular origin of H-RS cells has been questioned for a long time. Recently, using single cell amplification of Ig genes evidence was obtained that H-RS cells clonally arise from B-cells. Sequence analysis of rearranged Ig genes demonstrated that H-RS cells develop within the germinal centre. H-