Recent advances in biomedical polyurethane biostability and biodegradation

✍ Scribed by Anderson, James M.; Hiltner, Anne; Wiggins, Michael J.; Schubert, Mark A.; Collier, Terry O.; Kao, W. John; Mathur, Anshu B.

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 261 KB
• Volume: 46
• Category: Article
• ISSN: 0959-8103
• DOI: 10.1002/(sici)1097-0126(199807)46:3<163::aid-pi972>3.0.co;2-9

✦ Synopsis

This paper summarizes our recent e †orts to better understand the e †ects of antioxidants, the e †ects of strain-state, mechanistic studies of soft segment cleavage by reactive oxygen radicals, and the e †ects of di †erent soft segment chemistries on the biostability/biodegradation of polyether polyurethanes (PEUUs). In vivo cage implant system studies and in vitro cobalt ion/ hydrogen peroxide studies have been carried out on PEUUs and the polymers have been analysed by attenuated total reÑectance and Fourier transform infrared (ATR-FTIR) spectroscopy, and scanning electron microscopic (SEM) characterization of the PEUU surfaces. The natural antioxidant, vitamin E, has been shown to inhibit biodegradation and enhance biostability of PEUUs. Studies of the e †ect of stress state on PEUU biodegradation demonstrate that stress can inhibit biodegradation. While polyether soft segments may be cleaved by the presence of reactive oxygen radicals, the presence of oxygen has a profound e †ect in accelerating biodegradation. The biodegradation of polyurethanes may be inhibited by substituting di †erent chemistries such as polydimethylsiloxanes, polycarbonates, and hydrocarbon soft segments for the polyether soft segments. To safely utilize polyurethanes in long-term biomedical devices, the biodegradation mechanisms of polyurethane elastomers must be fully understood and subsequently prevented.

1998 SCI.