## Abstract Although the neurotoxicity of trimethyltin (TMT) is well known, mechanisms are still not clear. Glia have been proposed to mediate the toxic action of TMT on nerve cells. Accordingly, the effects of TMT were tested in primary neuronal cultures from rat cerebellum and compared to effects
Reassessing the role of astrocytes in ammonia neurotoxicity
β Scribed by Eid, Tore; Lee, Tih-Shih W
- Book ID
- 121653879
- Publisher
- Nature Publishing Group
- Year
- 2013
- Tongue
- English
- Weight
- 328 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1078-8956
- DOI
- 10.1038/nm.3420
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## Abstract Ammonia enters the brain by diffusion from the blood or cerebrospinal fluid, or is formed __in situ__ from the metabolism of endogenous nitrogenβcontaining substances. Despite its central importance in nitrogen homeostasis, excess ammonia is toxic to the central nervous system and its c