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Rearrangement reactions of taxanes: structural modifications of 10-deacetylbaccatin III.

✍ Scribed by Anne Wahl; Françoise Guéritte-Voegelein; Daniel Guénard; Marie-Thérèse Le Goff; Pierre Potier

Book ID
108372606
Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
705 KB
Volume
48
Category
Article
ISSN
0040-4020

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Paclitaxel, docetaxel and a series of new analogs synthesized from 14␤-hydroxy-10-deacetylbaccatin III (14-OH-DAB), a natural diterpene closely related to the core synthon of the 2 above prototypes, were tested in vitro for their growth-inhibitory activity on different human cancer cell lines, inclu