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Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe

โœ Scribed by Nicholas R. Abu-Absi; Brian M. Kenty; Maryann Ehly Cuellar; Michael C. Borys; Sivakesava Sakhamuri; David J. Strachan; Michael C. Hausladen; Zheng Jian Li


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
298 KB
Volume
108
Category
Article
ISSN
0006-3592

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In-line and real-time process monitoring
โœ De Beer, T. R.M. (author);Vercruysse, P. (author);Burggraeve, A. (author);Quinte ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons Inc. ๐ŸŒ English โš– 755 KB

The aim of the present study was to examine the complementary properties of Raman and near infrared (NIR) spectroscopy as PAT tools for the fast, noninvasive, nondestructive and in-line process monitoring of a freeze drying process. Therefore, Raman and NIR probes were built in the freeze dryer cham