Readministration of helper-dependent adenovirus to mouse lung
β Scribed by Koehler, D R; Martin, B; Corey, M; Palmer, D; Ng, P; Tanswell, A K; Hu, J
- Book ID
- 110039766
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 244 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0969-7128
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Background Poor transduction of the ciliated airway epithelium and inefficient airway delivery of viral vectors are common difficulties encountered in lung gene therapy trials with large animals and humans. ## Methods We delivered a helper-dependent adenovirus vector, incorporating a human epithe
## Abstract ## Background The helperβdependent (HD) adenoviral (Ad) vector relies on a helper virus to provide viral proteins for vector amplification. HDβAd vectors can significantly increase therapeutic gene expression and improve safety. However, the yield of an HDβAd vector is generally lower