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Helper-dependent adenovirus vectors: their use as a gene delivery system to neurons

✍ Scribed by Cregan, S P; MacLaurin, J; Gendron, T F; Callaghan, S M; Park, D S; Parks, R J; Graham, F L; Morley, P; Slack, R S

Book ID: 110038702
Publisher: Nature Publishing Group
Year: 2000
Tongue: English
Weight: 344 KB
Volume: 7
Category: Article
ISSN: 0969-7128
DOI: 10.1038/sj.gt.3301208

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## Abstract ## Background The helper‐dependent adenovirus (HDAd) vector is less immunogenic and has a larger cloning capacity of up to 37 kb enough to carry the full‐length dystrophin cDNA. However, high and long‐term expression of dystrophin transduced to mature muscle still remains difficult. On