𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Reactivity, SCE induction and mutagenicity of benzyl chloride derivatives

✍ Scribed by K. Hemminki; K. Falck; K. Linnainmaa

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
475 KB
Volume
3
Category
Article
ISSN
0260-437X

No coin nor oath required. For personal study only.

✦ Synopsis

Benzyl chloride, benzyl bromide, p-methylbenzyl chloride, and p-nitrobenzyl chloride were used to study chemical reactivity with 4-( p-nitrobenzy1)-pyridine (NBP), and with guanosine in vitro, in relation to mutagenic potency in S. typhimunum and sister chromatid exchange (SCE) induction in CHO cells. Benzyl bromide was found to be the most reactive compound, followed by p-methylbenzyl chloride, benzyl chloride and p-nitrobenzyl chloride. The order of mutagenicity was p-nitrobenzyl chloride S benzyl bromide > benzyl chloride % p-methylbenzyl chloride. The compounds tested caused base-pair mutations only. The order of WE-inducing ability decreased as follows: benzyl bromide > benzyl chloride p-nitrobenzyl chloride = p-methylbenzyl chloride. The particularly high mutagenicity of p-nitrobenzyl chloride in bacteria may be due to reactions other than direct aralkylation, or it may react particularly actively with DNA. Among the other compounds, benzyl bromide was the most active aralkylating compound, mutagen and SCE inducer. The results suggested that reaction of NZ of guanine, as compared with N-7 of guanine, failed to show any remarkable mutagenicity or SCE induction, since p-methylbenzyl chloride, reacting preferentially at N2 of guanosine, failed to show unexceptional potency. chromatid exchange.

πŸ“œ SIMILAR VOLUMES

Molecular polarizability and bond polari
Molecular polarizability and bond polarizability derivatives of benzyl chloride and benzyl bromide
✍ V. Kumar; U.P. Verma; A.N. Pandey πŸ“‚ Article πŸ“… 1978 πŸ› Elsevier Science 🌐 English βš– 212 KB

The delta function potential model of chemical binding has been employed to compute the bond and molecular polarizabilities of benzyl chloride and benzyl bromide. The transferabdity of bond parallel component has been examined. The semiempirical equations proposed by Long and Plane, and Lippincott a

Synthesis and Reactivity of Bis(phosphol
Synthesis and Reactivity of Bis(phospholyl)neodymium(III) and -samarium(III) Chlorides and Alkyl Derivatives
✍ FranΓ§ois Nief; Philippe Riant; Louis Ricard; Pascale Desmurs; Denise Baudry-Barb πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 255 KB πŸ‘ 2 views

The reaction of 2,3,4,5-tetramethylphospholylpotassium alkyl complexes [(C 4 Me 4 P) 2 LnCH(SiMe 3 ) 2 ]; these complexes were most efficiently prepared from [LnCl 3 (THF) x ], [C 4 Me 4 PK] with [LnCl 3 (THF) x ] (Ln = Nd, Sm) in a 2:1 ratio gave unsolvated ate complexes of the formula [KC 4 Me 4 P

An Investigation of the Solid-State Phot
An Investigation of the Solid-State Photochemistry of Ξ±-Mesitylacetophenone Derivatives: Asymmetric Induction Studies and Crystal Structure–Reactivity Relationships
✍ Eugene Cheung; Katja Rademacher; John R. Scheffer; James Trotter πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 208 KB

AbstractÐThe photochemical conversion of a series of a-mesitylacetophenone derivatives into 2-indanols via d-hydrogen abstraction has been investigated in the solid state. A correlation between solid-state reactivity and crystal structure has been established for this type of reaction. For the seven