Reactivity of active center analogs of Cu2Zn2superoxide dismutase on activated polymorphonuclear leukocytes
✍ Scribed by Ralf Miesel; Hans-Jürgen Hartmann; Yuejin Li; Ulrich Weser
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 562 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0360-3997
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Atomic partial charges for three model systems that mimic the metal-ligand moiety of the active site in the enzyme Cu, Zn superoxide dismutase (SOD) have been calculated at the ab initio level. The model systems include copper and zinc complexes with imidazole, formate and ammonia ligands. The parti
In addition to the well known catalytically accelerated O2 dismutation, Cu2Zn2 superoxide dismutase (SOD) reversibly reduces NO to NO-with the consequence of a prolonged half-life of NO. This alternative reactivity was examined in the presence of the intact CuZn enzyme and a diSchiff base copper com