Reactivity and the mechanisms of reactions of β-sultams with nucleophiles
✍ Scribed by Wood, J. Matthew; Hinchliffe, Paul S.; Laws, Andrew P.; Page, Michael I.
- Book ID
- 111966497
- Publisher
- Royal Society of Chemistry
- Year
- 2002
- Tongue
- English
- Weight
- 216 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1472-779X
- DOI
- 10.1039/b200184e
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AbstractÐb-Lactam antibiotics display a range of biological activities. The origin of this diverse biological activity is discussed with reference to the chemical reactivity of the small ring system. The reactions of b-sultams and b-phospholactams with simple nucleophiles are reported and their pote
The preparation of 4carbomefhauy-I ,2-thiazetidine-l, l -dimides from carbometw-methanesu2fonyl chioti and imines is described. The ability of p-lactam antibiotics to acylate bacterial cell wall enzymes provides the biochemical basis for their bactericidal action. Although structural analogs of p-la