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Reactive oxygen species in choline deficiency-induced apoptosis in rat hepatocytes

✍ Scribed by Wei-Xing Guo; Quentin N. Pye; Kelly S. Williamson; Charles A. Stewart; Kenneth L. Hensley; Yashige Kotake; Robert A. Floyd; Robert H. Broyles

Book ID: 113629305
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 462 KB
Volume: 37
Category: Article
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2004.06.036

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## Abstract Transforming growth factor‐β1 (TGFβ1) is a multifunctional cytokine that is over expressed during liver hepatocytes injury and regeneration. SV40‐transformed CWSV‐1 rat hepatocytes that are p53‐defective undergo apoptosis in response to choline deficiency (CD) or TGFβ1, which mediates C