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Reactive oxygen species activate focal adhesion kinase, paxillin and P130CAS tyrosine phosphorylation in endothelial cells

✍ Scribed by Alexia Gozin; Elisabeth Franzini; Valérie Andrieu; Lydie Da Costa; Emmanuelle Rollet-Labelle; Catherine Pasquier


Book ID
114276988
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
522 KB
Volume
25
Category
Article
ISSN
0891-5849

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## Abstract Treatment of intact Swiss 3T3 cells with calyculin‐A, an inhibitor of myosin light chain (MLC) phosphatase, induces tyrosine phosphorylation of p125^Fak^ in a sharply concentration‐ and time‐dependent manner. Maximal stimulation was 4.2 ± 2.1‐fold (n = 14). The stimulatory effect of cal