Y-27632, an Inhibitor of Rho-Associated Kinases, Prevents Tyrosine Phosphorylation of Focal Adhesion Kinase and Paxillin Induced by Bombesin: Dissociation from Tyrosine Phosphorylation of p130cas
β Scribed by James Sinnett-Smith; J.Adrian Lunn; Daniela Leopoldt; Enrique Rozengurt
- Book ID
- 115604004
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 370 KB
- Volume
- 266
- Category
- Article
- ISSN
- 0014-4827
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## Abstract Tyrosine phosphorylation of the nonreceptor tyrosine kinase p125 focal adhesion kinase (FAK) and the adapter protein paxillin is rapidly increased by multiple agonists, including bombesin (BOM) and lysophosphatidic acid (LPA), through heptahelical G proteinβcoupled receptors (GPCRs). Th
The experiments presented here were designed to examine the contribution of the extracellular signal-regulated mitogen-activated protein kinases (ERKs) to the tyrosine phosphorylation of the focal adhesion proteins p125 Fak , p130 Cas , and paxillin induced by G protein-coupled receptors (GPCRs) and