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Reactive nitrogen and oxygen species in interleukin-1-mediated DNA damage associated with osteoarthritis

✍ Scribed by C.M. Davies; F. Guilak; J.B. Weinberg; B. Fermor


Book ID
113732708
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
242 KB
Volume
16
Category
Article
ISSN
1063-4584

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## Abstract Cisplatin is a broad‐spectrum anticancer drug that is also widely used in experimental studies on DNA damage‐induced apoptosis. Induction of apoptosis within 24–48 hr requires cisplatin concentrations that are at least one order of magnitude higher than the IC~50~. Here, we show that su