Reactive changes in the mandible in the presence of squamous cell carcinoma

✍ Scribed by McGregor, Alan D. ;MacDonald, D. Gordon

• Publisher: Wiley (John Wiley & Sons)
• Year: 1988
• Weight: 763 KB
• Volume: 10
• Category: Article
• ISSN: 0148-6403
• DOI: 10.1002/hed.2890100604

✦ Synopsis

A series of 80 mandibles, which were removed as part of composite resections for primary intraoral squamous cell carcinoma, was examined. O f these, 58 were nonirradiated and 22 were previously irradiated. Several changes were observed in the nonirradiated mandible in response to invading tumor. Deposition of new bone was obvious on the periosteal and endosteal surfaces. Osteoclastic resorption of bone was prominent and there was replacement of hemopoietic marrow by fibrous tissue. By contrast, it was found in the irradiated specimens that osteoblastic activity was absent but that osteoclastic activity persisted. The hemopoietic marrow was replaced by fibrous tissue. The lack of osteoblastic activity was interpreted as being due to irradiation. The extent of these changes and their relationship to the invading tumor have implications for both surgeon and pathologist. HEAD & NECK SURGERY 10:378-386, 1988

I n normal adult bone there is a continuous but slow process of remodelling, involving osteoclastic resorption and osteoblastic activity forming new bone. These processes mainly involve the Acknowledgments: The authors thank the Consultants in Plastic and Maxillofacial Surgery at Canniesburn Hospital, from whose cases the material for this study derived. Thanks are also due to Miss