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Reactivation of telomerase activity in telomerase-deficient human cells by the pseudourydine synthase domain of dyskerin

✍ Scribed by R. Machado-Pinilla; I. Sanchez-Perez; J.R. Murguia; L. Sastre; R. Perona

Book ID
119598449
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
84 KB
Volume
6
Category
Article
ISSN
1359-6349

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## Abstract Ribozyme possesses specific endoribonuclease activity and catalyzes the hydrolysis of specific phosphodiester bonds, which results in the cleavage of target RNA sequences. Here, we evaluated the ability of hammerhead ribozymes targeting human telomerase RNA (hTR) to inhibit the catalyti