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Reactivation of Syk gene by AZA suppresses metastasis but not proliferation of breast cancer cells

✍ Scribed by Tian-Song Xia, Jing-Ping Shi, Qiang Ding, Xiao-An Liu, Yi Zhao, Yue-Xian Liu, Jian-Guo Xia, Shui Wang, Yong-Bin Ding


Book ID
113093633
Publisher
Springer US
Year
2011
Tongue
English
Weight
356 KB
Volume
29
Category
Article
ISSN
1357-0560

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The gene product of spleen tyrosine kinase (SYK) has been implicated in the suppression of breast cancer invasion. We previously reported that SYK expression is lost in a subset of breast cancer; primarily by methylation-mediated gene silencing. In our study, we explored the possibility of using a D