Reactions with Heterocyclic Amidines, XI. Syntheses of New 2-Aminopyrazolo[1,5—a]pyrimidines and 2-Amino[1,5-c]-as-triazines

✍ Scribed by Ezzat M. Kandeel; Victorin B. Baghos; Ivon S. Mohareb; Mohamed H. Elnagdi

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 356 KB
• Volume: 316
• Category: Article
• ISSN: 0365-6233
• DOI: 10.1002/ardp.19833160813

✦ Synopsis

Several new aminopyrazolo[ l,S-u]pyrimidines were synthesised by condensation of 33-diami-no4-(ethoxycarbonyl)pyrazoIe (1) with b-bifunctional reagents. The azo analogues of pyrazolo[l,5-u]pyrimidines, i. e. pyrazolo[l,4-c]-ar-triazines, were synthesised by coupling of diazotized 1 with agents containing active hydrogen. Reaktionen mit heteroqLliscaen Amidinen, ll. M i t t . : Syntheae e w e r nener Aminopyrrzolo[l,S-n]pyrhnicUn-Derivate und 2 -A m i n o [ l , S -c ] -~-t e Einige neue Aminopyrazolo[ 1,5-a]pyrimidin-Derivate wurden durch Umsetzung von 3,5-Diamino-4-ethoxycarbonyl-pyrazol(l) mit p-bifunktionellen Reagenzien synthetisiert . Die Azoanalogen Pyrazolo[l,S-c]-as-tri~ne wurden durch Umsetzung von diazotiertem 1 mit Reagenzien mit aktivem Wasserstoff hergestellt.

Schistosomiasis is considered to be one of the most difficult diseases to treat"). Accordingly considerable attention has been directed toward development of chemotherapeutic agents. Recently Sengu at a l ' ) have reported that certain pyrazolo[ 1 ,5-u]pyrimidines have considerable antischistosomal activity.