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Reactions of Pyrazolylborate−Zinc−Hydroxide Complexes Related to β-Lactamase Activity

✍ Scribed by Gross, Florian; Vahrenkamp, Heinrich


Book ID
127181193
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
187 KB
Volume
44
Category
Article
ISSN
0020-1669

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## Abstract A series of highly preorganized pyrazolate‐based dinuclear zinc complexes has been studied as functional synthetic analogues of metallo‐β‐lactamases, a class of bacterial enzymes that cause serious clinical problems because of their degradation of common β‐lactam antibiotics. We have in