Biomimetic Hydrolysis of Penicillin G Ca
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Bernhard Bauer-Siebenlist; Sebastian Dechert; Franc Meyer
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Article
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2005
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John Wiley and Sons
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English
⚖ 258 KB
## Abstract A series of highly preorganized pyrazolate‐based dinuclear zinc complexes has been studied as functional synthetic analogues of metallo‐β‐lactamases, a class of bacterial enzymes that cause serious clinical problems because of their degradation of common β‐lactam antibiotics. We have in