Reactions of platinum(II) dipicolinate complex with amino acids—chelation and isomerization

✍ Scribed by Sukalpa Dey; Pradyot Banerjee

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 183 KB
• Volume: 34
• Category: Article
• ISSN: 0538-8066
• DOI: 10.1002/kin.10051

✦ Synopsis

Abstract

The kinetic course of the reactions of [Pt(dipic~tr~)Cl]^−^ (where H~2~dipic = pyridine‐2,6‐dicarboxylic acid; bonded in tridentate mode) with glycine, β‐alanine, and L‐histidine was followed at 25°C in aqueous medium at pH 3.00–10.73 at I = 0.5 mol dm^−3^ (LiClO~4~) spectrophotometrically and through ^1^H NMR spectral analysis. The selectivity of platinum(II) toward the amino acids with regard to chelation and isomerization is controlled by donor atoms and steric properties. The aquation equilibrium of the designated platinum(II) complex also affects the binding rate in the case of glycine and β‐alanine. The reaction products have been isolated and characterized through ^1^H NMR spectra. © 2002 Wiley Periodicals, Inc. Int J Chem Kinet 34: 262–270, 2002