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Reactions of nucleic acid bases with α-acetylenic esters : Synthesis and enzymatic evaluation of chemically modified nucleotides

✍ Scribed by Françoise THOMÉ; Frédérique BLOIS; Anna OLOMUCKI; Martin OLOMUCKI


Book ID
115124900
Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
581 KB
Volume
162
Category
Article
ISSN
1432-1327

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Reaction of nucleobases with α-acetyleni
✍ M. Olomucki; J.Y. Le Gall; S. Colinart; F. Durant; B. Norberg; G. Evrard 📂 Article 📅 1984 🏛 Elsevier Science 🌐 French ⚖ 252 KB

The NH2 group and the adjacent ring nitrogen of adenosine and cytidine react with a-acetylenic esters by addition across the triple bond and formation of a lactam with the ester group. We have recently shown that chlorotetrolic (4-chloro-2-butynoic) esters', C1CH2-CzC-COOR, react under mild conditi