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Reaction of nucleobases with α-acetylenic esters, potentially useful for chemical modification of nucleic acids

✍ Scribed by M. Olomucki; J.Y. Le Gall; S. Colinart; F. Durant; B. Norberg; G. Evrard

Publisher: Elsevier Science
Year: 1984
Tongue: French
Weight: 252 KB
Volume: 25
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)91050-0

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✦ Synopsis

The NH2 group and the adjacent ring nitrogen of adenosine and cytidine react with a-acetylenic esters by addition across the triple bond and formation of a lactam with the ester group.

We have recently shown that chlorotetrolic (4-chloro-2-butynoic) esters', C1CH2-CzC-COOR, react under mild conditions with nucleophiles analogous to those present in proteins2. Tests with small model molecules and with proteins

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