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New reaction of adenine and cytosine derivatives, potentially useful for nucleic acids modification.

✍ Scribed by N.K. Kochetkov; V.N. Shibaev; A.A. Kost

Publisher
Elsevier Science
Year
1971
Tongue
French
Weight
202 KB
Volume
12
Category
Article
ISSN
0040-4039

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✦ Synopsis

The chemical modification of the base residues in nucleic acids is of importance for structural and functional investigation of RNA and DNA /I/.

A search of new specific chemical reactions for this purpose seems to be essential for the future development of this field.

We wish to report our observations about interaction of chloroacetaldehyde with nucleic acid components. This reaction may form a basis for the new method of nucleic acid modification. We have found that chloroacetaldehyde reacts readily with 9-N-methyladenine and I-N-methylcytosine in weakly acidic aqueous solutions (in former case , addition of ethanol is necessary for homogeneity of the reaction mixture)to give 3-methylimidazo/2,1-i/purinetAj from 9-N-methyladenine.

COCw,CHO

The analytical sample of p&chlorate of Ahas m.p. 295-6Β°(decomp.).

πŸ“œ SIMILAR VOLUMES

Reaction of nucleobases with Ξ±-acetyleni
Reaction of nucleobases with Ξ±-acetylenic esters, potentially useful for chemical modification of nucleic acids
✍ M. Olomucki; J.Y. Le Gall; S. Colinart; F. Durant; B. Norberg; G. Evrard πŸ“‚ Article πŸ“… 1984 πŸ› Elsevier Science 🌐 French βš– 252 KB

The NH2 group and the adjacent ring nitrogen of adenosine and cytidine react with a-acetylenic esters by addition across the triple bond and formation of a lactam with the ester group. We have recently shown that chlorotetrolic (4-chloro-2-butynoic) esters', C1CH2-CzC-COOR, react under mild conditi