Reactions of N-phthalylamino acid chlorides with trialkyl phosphites

✍ Scribed by Zyta Ziora; Alina Maly; Barbara Lejczak; Pawel Kafarski; Jolanta Holband; Grażyna Wójcik

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 218 KB
• Volume: 11
• Category: Article
• ISSN: 1042-7163
• DOI: 10.1002/(sici)1098-1071(2000)11:3<232::aid-hc12>3.0.co;2-u

✦ Synopsis

Reaction of commercially available trialkyl phosphites with N-phthalylamino acids gave mixtures of seven products, whereas the same reaction carried out with pure triethyl phosphite yielded only the desired 2-(N-phthalylamino)-1-oxoalkanephosphonates. These compounds underwent rearrangement to the same types of products that were obtained with the commercial phosphites. This latter series of reactions was promoted by the presence of dialkyl phosphites.